Synonyms : 2-Chloro-4-picoline
CAS No. : [3678-62-4]
Molecular Formula : C6H6CIN
Formula weight : 127.57


2-Chloro-4-picoline (2-Chloro-4-methylpyridine) has been used in the determination of gas-phase basicity of several relatively small organic molecules that are used in the MALDI


Synonym: 2-Chloro-4-Picoline
CAS Number: 3678-62-4
Chemical Formula: C6H6CIN
Molecular Weight: 127.57 g/mol


C6H6CIN is basically considered as a halogenated heterocycle organic compound which is generally used in procurement and amalgamation to react with C7H6BF3O2 acid and thus form 2-(3,5-bis(trifluoromethyl)phenyl)-4-methylpyridine by palladium-catalyzed that essentially utilizes cross-coupling reaction.
In the main result of this reaction is 4-chloro-3-methylpyridine, the percentage of 2-chloro-4methylpyridine is generally below 25%. There are various other methods of preparation that have recently come up.


The preparation of 2-chloro-4-methylpyridine involves STR6 reaction with 3-methylpyridine 1-oxide with phosphorus oxychloride. This reaction takes place in the presence of an underlying organic nitrogen mixture at a diluent temperature of-50° C and +50° C.
It is quite a surprising fact that the preparation of 2-chloro-4-methylpyridine through basic organic nitrogen compounds can result in significantly higher yield. Since using phosphorus oxychloride and basic organic nitrogen mixtures together in the reaction is more likely to generate this by-product.
One of the major advantages of using this process according to many inventiveness is that in addition to the good yield of the aspired product, it is factual that the proportion of isomeric by-products is significantly less in comparison to any other known synthetic process.
Besides, the pure compound formed can, if wanted, be easily separated from the reactant products by a standard means, for example by distillation. Hence, this method is considered as a valuable improvement of industrial processes according to the invention.


2-Chloro-4-methylpyridine is effectively used in the determination of gas-phase basicity of several relatively small organic molecules that are used in the process of MALD.
This is also used as a reagent in the synthesis of the mGLUR5 modulators imidazolyl-ethynyl-pyridines which is considered as a potential antipsychotics.
It is also has a wide application in the preparation of trifluoromethyl(pyrimidinyl) azetidinecarboxamides as potent, orally bioavailable TGR5 agonists.