Chemical Name : 2-AMINO PYRIDINE

Synonyms : α-Amino Pyridine, 2-Pyridinamine
CAS No. : [504-29-0]
Molecular Formula : C5H6N2
Formula weight : 94.12


2-Aminopyridine is an organic compound with the formula H2NC5H4N. It is one of three isomeric aminopyridines. It is a colourless solid that is used in the production of the drugs piroxicam, sulfapyridine, tenoxicam, and tripelennamine. It is produced by the reaction of sodium amide with pyridine, the Chichibabin reaction.


Appearance: Colourless Solid
CAS Number: 504-29-0
Chemical Formula: C5H6N2
Molecular Weight: 94.117 g/mol
Melting Point: 59 to 60 °C


The organic compound 2-Aminopyridine having the chemical formula C5H6N2 and formula H2NC5H4N is one of the three isomeric aminopyridines. Basically, it is witnessed as a colourless solid component that is used in the production of the drugs which specifically includes piroxicam, sulfapyridine, and tripelennamine. It is generally produced by the reaction of sodium amide with pyridine which is called as the Chichibabin reaction.

Preparation of 2-Aminopyridine

The synthesis of 2-aminopyridine from the corresponding pyridine-N-oxides can be prepared by a general and facile one-pot amination procedure which is considered as a mild alternative to SNAr chemistry. The phosphonium salt PyBroP is used with a variety of amines and heterocyclic-N-oxides to participate effectively in the transformation as a means of substrate activation.


2- aminopyridine tends to react vigorously with chlorosulfonyl isocyanate at 0 °C which leaves a urea intermediate as an end product. Also, this in the presence of diisopropylethylamine is reported to yield pyrido-thiatriazine-one-dioxide.
It is also reportedly observed that 2-aminopyridine derivatives having the formula of ##STR2## where R1 is Cyani or carboxyl can be advantageously obtained if a quaternary ammonium compound. The different radicals present here like R2 and R3 can be identical or different and each of them is an aliphatic radical.

Uses of 2-Aminopyridine

Aminopyridines are considered the essential members of a family of Monoamino and diamino derivatives of pyridine. Their principal mechanism and work of action are dependent on the dosages of the blockade of voltage-gated potassium channels. Thus, it is effectively used as a research tool in characterizing subtypes of the potassium channel.
It is also being used as a drug, to manage some of the symptoms of multiple sclerosis. It is also found to be broadly used for symptomatic improvement of walking in adults who are dealing with several variations of the disease.
The current review regarding aminopyridine summarizes the evidence of its use in neurological conditions.